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KMID : 0364820160520040482
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Korean Journal of Microbiology
2016 Volume.52 No. 4 p.482 ~ p.486
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Anti-tumor effect of Inonotus obliquus in xenograft animals with EBV+human gastric carcinoma
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Lee Seul-Ki
Cho Hyo-Sun
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Abstract
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Inonotus obliquus is a medicinal mushroom with a variety of biological activities. It has reported to have strong anti-cancer, antioxidant and anti-inflammatory properties. EBV+ gastric carcinoma is one of the most common EBV-associated cancers that were caused by latent EBV infection. In this study, we investigated the anti-cancer effects of ethanol extract of I. obliquus using in vivo xenograft animal models implanted with EBV+ human gastric carcinoma (SNU719). We also explored the molecular mechanisms responsible for its anti-cancer activity. The result indicated that the extract of I. obliquus had an anti-cancer effect in in vivo xenograft mice with EBV+ gastric carcinoma (SNU719). Extract of I. obliquus also showed a great effect on inducing the expression of p53, p21 and Bax in tumor tissue derived from EBV+ human gastric carcinoma, and these were correlated with increased expressions of the cleaved forms of caspase-9 and Parp. Also, I. obliquus attenuated the expression of viral proteins, BZLF-1 and LMP-2 in tumor tissue from EBV+ human gastric carcinoma.
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KEYWORD
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Inonotus obliquus, EBV+human gastric carcinoma, caspase-9, p53, PARP
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